Hate your nose? Blame your ancient cousins! Neanderthal DNA dictates the shape, study


It’s something that many people are self-conscious of, and if you not a fan of your nose, we finally know who to blame. 

Scientists have revealed that Neanderthal DNA helps dictate the shape of your nose.  

A new study led by UCL researchers found that a particular gene, which leads to a taller nose, may have been the product of natural selection as ancient humans adapted to colder climates after leaving Africa.

Dr Kaustubh Adhikari, who led the study, said: ‘In the last 15 years, since the Neanderthal genome has been sequenced, we have been able to learn that our own ancestors apparently interbred with Neanderthals, leaving us with little bits of their DNA.

‘Here, we find that some DNA inherited from Neanderthals influences the shape of our faces.

It's something that many people are self-conscious of, and if you not a fan of your nose, we finally know who to blame (stock image)

It’s something that many people are self-conscious of, and if you not a fan of your nose, we finally know who to blame (stock image)

According to the study, researchers newly identified 33 genome regions associated with face shape. They were able to replicate 26 in comparisons with data from other ethnicities using people in east Asia, Europe, or Africa

According to the study, researchers newly identified 33 genome regions associated with face shape. They were able to replicate 26 in comparisons with data from other ethnicities using people in east Asia, Europe, or Africa

‘This could have been helpful to our ancestors, as it has been passed down for thousands of generations.’

The researchers used data from more than 6,000 people across Latin America, of mixed European, Native American and African ancestry, who are part of the UCL-led Candela study, which recruited from Brazil, Colombia, Chile, Mexico and Peru.

Genetic information from the people was compared to photographs of their faces.

To see how different facial traits were linked to the presence of different genetic markers, the researchers looked specifically at distances between points on their faces, such as the tip of the nose or the edge of the lips.

According to the study, researchers newly identified 33 genome regions associated with face shape.

They were able to replicate 26 in comparisons with data from other ethnicities using people in east Asia, Europe, or Africa.

In one genome region in particular, called ATF3, the researchers found that many people in their study with Native American ancestry (as well as others with east Asian ancestry from another group) had genetic material in this gene that was inherited from the Neanderthals.

They found that this contributed to increased nasal height.

This gene region has signs of natural selection, suggesting that it conferred an advantage for those carrying the genetic material, the researchers say.

First author Dr Qing Li, Fudan University, said: ‘It has long been speculated that the shape of our noses is determined by natural selection; as our noses can help us to regulate the temperature and humidity of the air we breathe in, different shaped noses may be better suited to different climates that our ancestors lived in.

A new study led by UCL researchers found that a particular gene, which leads to a taller nose, may have been the product of natural selection as ancient humans adapted to colder climates after leaving Africa

A new study led by UCL researchers found that a particular gene, which leads to a taller nose, may have been the product of natural selection as ancient humans adapted to colder climates after leaving Africa

‘The gene we have identified here may have been inherited from Neanderthals to help humans adapt to colder climates as our ancestors moved out of Africa.’

Co-corresponding author Professor Andres Ruiz-Linares, Fudan University, UCL Genetics, Evolution & Environment, and Aix-Marseille University, added: ‘Most genetic studies of human diversity have investigated the genes of Europeans; our study’s diverse sample of Latin American participants broadens the reach of genetic study findings, helping us to better understand the genetics of all humans.’

Researchers say the finding, published in Communications Biology, is the second discovery of DNA from archaic humans, distinct from Homo sapiens, affecting our face shape.

The same team discovered in a 2021 paper that a gene influencing lip shape was inherited from the ancient Denisovans.

WHAT KILLED OFF THE NEANDERTHALS?

The first Homo sapiens reached Europe around 43,000 years ago, replacing the Neanderthals there approximately 3,000 years later.

There are many theories as to what drove the downfall of the Neanderthals.

Experts have suggested that early humans may have carried tropical diseases with them from Africa that wiped out their ape-like cousins.

Migran

The first Homo sapiens reached Europe around 43,000 years ago, replacing the Neanderthals (model pictured) there approximately 3,000 years later 

Others claim that plummeting temperatures due to climate change wiped out the Neanderthals.

The predominant theory is that early humans killed off the species through competition for food and habitat.

Homo sapiens’ superior brain power and hunting techniques meant the Neanderthals couldn’t compete.

Based on scans of Neanderthal skulls, a new theory suggests the heavy-browed hominids lacked key human brain regions vital for memory, thinking and communication skills.

That would have affected their social and cognitive abilities – and could have killed them off as they were unable to adapt to climate change.



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